The database of various piRNA associated data to support piRNA functional study

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piRBase is a manually curated resource of piRNAs, which focused on piRNA function analyses as well as piRNA annotation.

piRBase provides the following information and tools to facilitate piRNA function analyses:
The number of piRNA sequences has reached 173 million, from 264 datasets in 21 organisms.
piRBase classifies piRNAs by biogenesis according to genomic annotation.
Regulatory piRNAs and their mRNA targets are extracted from the literature. Predicted piRNA target lncRNAs are also added to the present release.
piRBase combines DNA methylation data and H3K9me3 data to facilitate studies of piRNA function in epigenetic regulation.
8 types of cancers (Breast, Bladder, Pancreas, Gastric, Liver, Kidney, Myeloma and Colorectal cancer) related piRNAs are included.
Genome Browser provides improved integration and visualization of the relations between piRNA data and other related information.


> Oct. 2018: piRBase article published online on Nucleic Acids Research

> Aug. 2018: piRBase release v2.0
Online tools are added
The information of cancer related piRNAs is added
New piRNA targets are added
New piRNA records are added

> Nov. 2014: piRBase release v1.0

Please cite the following article in addition to the primary data sources:
piRBase: a comprehensive database of piRNA sequences. Nucleic Acids Res. 2018; doi: 10.1093/nar/gky1043
piRBase: a web resource assisting piRNA functional study. Database 2014; doi: 10.1093/database/bau110

Any questions or suggestions please contact: Shunmin He heshunmin@ibp.ac.cn.

This is open data distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. If you are a commercial user, please contact us.